aprzybylo-jozefowicz@ichf.edu.pl

A new approach for gene delivery into retinal bipolar cells
18.12.2024

A new approach for gene delivery into retinal bipolar cells

To date, various approaches have been used to restore some visual functions in affected patients, primarily human derived retinal organoids and gene therapies. First directly administered Adeno-associated virus (AAV) based gene therapy approved by U.S. Food and Drug Administration (FDA), Luxturna, significantly improved the vision of patients with retinal dystrophy at low light levels. Nevertheless, […]

All fiber imaging probes
17.12.2024

All fiber imaging probes

Dr. Karnowski developed expertise in fiber imaging probes during his postdoctoral research at the University of Western Australia. He continued this line of research through the NAWA Polish Returns project, which was integrated into the broader ICTER research initiatives. Our team proposed an innovative design for imaging probes that strategically combines the advantages of previous […]

Anterior segment structural and functional imaging
17.12.2024

Anterior segment structural and functional imaging

The anterior chamber of the eye plays a critical role in our visual mechanism, serving dual purposes of protection and optical functionality. This vital anatomical region acts not only as a protective barrier but also as a crucial optical pathway that focuses light onto the retina, enabling our visual perception of the world. Our comprehensive […]

Bridging biology and optics
17.12.2024

Bridging biology and optics

Two-photon excitation fluorescence (TPEF) is emerging as a powerful imaging technique with superior penetration power in scattering media, allowing for functional imaging of biological tissues at a subcellular level. TPEF is commonly used in cancer diagnostics, as it enables the direct observation of metabolism within living cells. The technique is now widely used in various […]

Searching new biomarkers of Diabetic retinopathy (DR)
17.12.2024

Searching new biomarkers of Diabetic retinopathy (DR)

Diabetic retinopathy (DR) is a severe disease with a growing number of afflicted patients, which places a heavy burden on society, both socially and financially. While there are treatments available, they are not always effective and are usually administered when the disease is already at a developed stage with visible clinical manifestation. However, homeostasis at […]

Chimeric Rhodopsin as a novel optogenetic tool
16.12.2024

Chimeric Rhodopsin as a novel optogenetic tool

Visual impairments are affecting millions of people worldwide, and the number of visually disabled people is increasing due to the aging of the population and chronic diseases. By 2050, 61 million people will be blind, and 474 million will have moderate and severe vision impairment. Decrease or loss of vision impacts the lives of those […]

The role of the basal forebrain in visual processing
16.12.2024

The role of the basal forebrain in visual processing

There is a strong need to understand how our brain processes visual information and how different brain centers interact with each other. Vision is an essential sense in our life. Lack of such interaction disable performance of an attentive task or to memorize visual information. One of the structures heavily involved in cognitive processes and […]

A new approach of vision restoration based on modified Rabies virus tracing technique
16.12.2024

A new approach of vision restoration based on modified Rabies virus tracing technique

Eye, and particularly the retina, is a “window into the brain”. It reveals sufficient information about patient condition, and for humans, it is the main organ responsible for world perception. The retina is a very fragile and complex structure, located on the back of the eyes and is exposed to many environmental hazards leading to […]

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