Multimodal single-cell sequencing has emerged as a powerful tool, allowing the simultaneous measurement of multiple cellular parameters and providing a comprehensive view of complex biological systems. Nevertheless, translating the wealth of data into meaningful biological insights and clinical implications poses a significant challenge The tumor niche is a complex and dynamic cellular landscape, composed of various cell types, including malignant cells, endothelial cells, fibroblasts, immune cells etc. Single-cell sequencing has advanced cancer research by enabling the characterization of cancer cell diversity and the identification of specialized roles of tumor-supporting cells. In this context, will present the multimodal sequencing methods designed to tackle tumor heterogeneity and individual vanability, as well as discuss yielding biological interpretation from such data on an example of a single-cell profiling study of the immune niche in ghoblastoma
About the speaker
4. Lewicka is involved in developing j protocois for multimodal single-cell sequencing and contributing to bioinformatics analysis
