Natalia Ochocka-Lewicka, PhD
Dr. Natalia Ochocka-Lewicka obtained her Master’s degree in Neurosciences in 2016 from Charité Universitätsmedizin in Berlin and Vrije Universiteit of Amsterdam. In 2022, she earned her PhD in Biological Sciences.
Postdoctoral Researcher
cellular heterogeneity of the tumor microenvironment and sex differences in immune activation in response to tumors
Description
During her doctoral studies Dr. Ochocka-Lewicka studied the role of immune cells in glioma progression at the Nencki Institute of Experimental Biology in Warsaw. She was also engaged in commercial projects on TCR immunotherapies.
Dr. Ochocka-Lewicka was a leader of an NCN Preludium grant. She is also a laureate of the FNP START award and a co-author of 8 publications, including papers in Nature Communications and Cell Reports.
Publication list
- Ochocka N., Segit P., Wojnicki K., Cyranowski S., Swatler J., Jacek K., Grajkowska W., & Kaminska B. (2021). “Specialized functions and sexual dimorphism explain functional diversity of the myeloid populations during glioma progression.” Cell Reports 42 (2023), 111971 https://doi.org/10.1016/j.celrep.2022.111971
- Ochocka N., Segit P., Walentynowicz K. A., Wojnicki K., Cyranowski S., Swatler J., Mieczkowski J., & Kaminska B. (2021). ”Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages.” Nature Communications, 12(1151), https://doi.org/10.1038/s41467-021-21407-w
- Ochocka N, Kaminska B. “Microglia Diversity in Healthy and Diseased Brain: Insights from Single-Cell Omics.” International Journal of Molecular Science. 2021 Mar;22(6). DOI: 10.3390/ijms22063027.
- Kaminska B, Ochocka N, Segit P “Single-cell omics in dissecting immune microenvironment of malignant gliomas – challenges and perspectives” Cells 10(9), 2264 (2021). https://doi.org/10.3390/cells10092264
- Pilanc P, Wojnicki K, Roura AJ, Cyranowski S, Ellert-Miklaszewska A, Ochocka N, Gielniewski B, Grzybowski MM, Błaszczyk R, Stańczak PS, Dobrzański P, Kaminska B. “A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment.” Front Oncol. 2021 Aug 24;11:703465. doi: 10.3389/fonc.2021.703465.
- Ellert-Miklaszewska, A., Ochocka, N., Maleszewska, M., Ding, L., Laurini, E., Jiang, Y., Roura, A. J., Giorgio, S., Gielniewski, B., Pricl, S., Peng, L., & Kaminska, B. (2019). “Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector.” Nanomedicine, 14(18). https://doi.org/10.2217/nnm-2019-0176
- Guneykaya, D., Ivanov, A., Hernandez, D. P., Haage, V., Wojtas, B., Meyer, N., Maricos, M., Jordan, P., Buonfiglioli, A., Gielniewski, B., Ochocka, N., Cömert, C., Friedrich, C., Artiles, L. S., Kaminska, B., Mertins, P., Beule, D., Kettenmann, H., & Wolf, S. A. (2018). “Transcriptional and Translational Differences of Microglia from Male and Female Brains.” Cell Reports, 24(10), 2773–2783. https://doi.org/10.1016/j.celrep.2018.08.001
- Walentynowicz, K. A., Ochocka, N., Pasierbinska, M., Wojnicki, K., Stepniak, K., Mieczkowski, J., Ciechomska, I. A., & Kaminska, B. (2018). “In search for reliable markers of glioma-induced polarization of microglia.” Frontiers in Immunology, 9(JUN), 1–13. https://doi.org/10.3389/fimmu.2018.01329
Research projects
Research groups
We are interested in creating new approaches for comprehensive inference of developmental trajectories and delineation of cell atlases from single-cell data, understanding the role of cell-to-cell signaling and biological pathways in lineage commitment and transitions between cellular states.
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