Magdalena Banach-Orłowska, PhD
PhD, Institute of Biochemistry and Biophysics (PAS)
Group Coordinator & Lab Manager
Intracellular Signaling and Regulation of Gene Expression in Cancer Cells
Description
Dr. Magdalena Banach-Orłowska graduated from Biotechnology at the University of Warsaw. She obtained a PhD degree in Biochemistry at the Institute of Biochemistry and Biophysics (awarded with the Prime Minister award for a PhD thesis). She continued her scientific work as a postdoctoral fellow and senior researcher at the International Institute of Molecular and Cell Biology, and at the Medical University of Warsaw.
She led two scientific grants as a PI, co-promoted one PhD and published thirteen papers including twelve original (Scopus preview – Banach-Orłowska, Magdalena – Author details – Scopus). Her scientific interests focus mostly on intracellular signaling and regulation of gene expression in cancer cells.
Publication list
- Koppolu A, Maksym RB, Paskal W, Machnicki M, Rak B, Pępek M, Garbicz F, Pełka K, Kuśmierczyk Z, Jacko J, Rydzanicz M, Banach-Orłowska M, Stokłosa T, Płoski R, Malejczyk J, Włodarski PK., “Epithelial Cells of Deep Infiltrating Endometriosis Harbor Mutations in Cancer Driver Genes”, Cells, Mar 29;10(4):749, (2021)
- Maksymowicz M, Miączyńska M, Banach-Orłowska M., “Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor”, Cell Commun Signal., Nov 4;18(1):176, (2020)
- Banach-Orłowska M, Wyszyńska R, Pyrzyńska B, Maksymowicz M, Gołąb J, Miączyńska M, “Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling”, Cell Commun Signal. Dec 26;17(1):171, (2019 )
- Banach-Orłowska M, Jastrzębski K, Cendrowski J, Maksymowicz M, Wojciechowska K, Korostyński M, Moreau D, Gruenberg J, Miaczynska M., “The topology of the lymphotoxin β receptor that accumulates upon endolysosomal dysfunction dictates the NF-κB signaling outcome“, J Cell Sci., Nov 21;131(22):jcs218883, (2018)
- Mamińska A, Bartosik A, Banach-Orłowska M, Pilecka I, Jastrzębski K, Zdżalik-Bielecka D, Castanon I, Poulain M, Neyen C, Wolińska-Nizioł L, Toruń A, Szymańska E, Kowalczyk A, Piwocka K, Simonsen A, Stenmark H, Fürthauer M, González-Gaitán M, Miaczynska M., “ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors”, Sci Signal., Jan 19;9(411):ra8, (2016)
- Banach-Orlowska M, Szymanska E, Miaczynska M., “APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription.”, FEBS Lett., Feb 13;589(4):532-9, (2015)
- Pyrzynska B, Banach-Orlowska M, Teperek-Tkacz M, Miekus K, Drabik G, Majka M, Miaczynska M., “Multifunctional protein APPL2 contributes to survival of human glioma cells”, Mol Oncol.Feb;7(1):67-84, (2013)
- Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M., „Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.”, Biochem J., Oct 12;423(3):389-400, (2009)
- Makiela-Dzbenska K, Jaszczur M, Banach-Orlowska M, Jonczyk P, Schaaper RM, Fijalkowska IJ., “Role of Escherichia coli DNA polymerase I in chromosomal DNA replication fidelity.”, Mol Microbiol., Dec;74(5):1114-27, (2009)
- Pilecka I, Banach-Orlowska M, Miaczynska M., “Nuclear functions of endocytic proteins.“, Eur J Cell Biol., Sep;86(9):533-47, (2007)
- Kuban W, Banach-Orlowska M, Schaaper RM, Jonczyk P, Fijalkowska IJ., „Role of DNA polymerase IV in Escherichia coli SOS mutator activity.“, J Bacteriol., Nov;188(22):7977-80, (2006)
- Banach-Orlowska M, Fijalkowska IJ, Schaaper RM, Jonczyk P., „DNA polymerase II as a fidelity factor in chromosomal DNA synthesis in Escherichia coli.”, Mol Microbiol., Oct;58(1):61-70, (2005)
- Kuban W, Banach-Orlowska M, Bialoskorska M, Lipowska A, Schaaper RM, Jonczyk P, Fijalkowska IJ., „Mutator phenotype resulting from DNA polymerase IV overproduction in Escherichia coli: preferential mutagenesis on the lagging strand.”, J Bacteriol., Oct;187(19):6862-6, (2005)
Research projects
Research groups
We are interested in creating new approaches for comprehensive inference of developmental trajectories and delineation of cell atlases from single-cell data, understanding the role of cell-to-cell signaling and biological pathways in lineage commitment and transitions between cellular states.
