{"id":13488,"date":"2025-06-03T16:00:00","date_gmt":"2025-06-03T16:00:00","guid":{"rendered":"https:\/\/icter.local\/seminar\/protein-degraders-new-insights-and-twists-of-molecular-mechanism-and-drug-design-2\/"},"modified":"2025-06-03T16:00:00","modified_gmt":"2025-06-03T16:00:00","slug":"protein-degraders-new-insights-and-twists-of-molecular-mechanism-and-drug-design-2","status":"publish","type":"seminar","link":"https:\/\/icter.jcd.pl\/pl\/seminar\/protein-degraders-new-insights-and-twists-of-molecular-mechanism-and-drug-design-2\/","title":{"rendered":"Protein degraders: New insights and twists of molecular mechanism and drug design"},"content":{"rendered":"<p>Prof. Ciulli opowie o degraderach bia\u0142ek, w tym PROTAC-ach i klejach molekularnych, kt\u00f3re kieruj\u0105 wybrane bia\u0142ka do ligaz E3, uruchamiaj\u0105c ich ubikwitynacj\u0119 i degradacj\u0119 w proteasomie. Jego zesp\u00f3\u0142 bada struktur\u0119 i mechanizmy tych oddzia\u0142ywa\u0144, a nast\u0119pnie wykorzystuje t\u0119 wiedz\u0119 do projektowania cz\u0105steczek wobec trudnych cel\u00f3w, takich jak BRD9, SMARCA2, KRAS i LRRK2. Wyk\u0142ad obejmie te\u017c nowe koncepcje, m.in. tr\u00f3jwarto\u015bciowe PROTAC-i, dynamiczne kombinatoryczne PROTAC-i i wewn\u0105trzcz\u0105steczkowe dwuwarto\u015bciowe kleje.<\/p>\n<h3>O prelegencie<\/h3>\n<p>Prof. Alessio Ciulli studiowa\u0142 chemi\u0119 we Florencji, a doktorat uzyska\u0142 jako Gates Scholar na Uniwersytecie Cambridge w 2006 r. Po sta\u017cu podoktorskim w Cambridge i kr\u00f3tkim pobycie na Yale University wr\u00f3ci\u0142 do Cambridge, gdzie za\u0142o\u017cy\u0142 w\u0142asne laboratorium. W 2013 r. otrzyma\u0142 ERC Starting Grant i przeni\u00f3s\u0142 si\u0119 na University of Dundee, gdzie w 2016 r. zosta\u0142 profesorem. Jest laureatem wielu nagr\u00f3d w dziedzinie biologii chemicznej i odkrywania lek\u00f3w.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prof. Ciulli opowie o degraderach bia\u0142ek, w tym PROTAC-ach i klejach molekularnych, kt\u00f3re kieruj\u0105 wybrane bia\u0142ka do ligaz E3, uruchamiaj\u0105c ich ubikwitynacj\u0119 i degradacj\u0119 w proteasomie. Jego zesp\u00f3\u0142 bada struktur\u0119 i mechanizmy tych oddzia\u0142ywa\u0144, a nast\u0119pnie wykorzystuje t\u0119 wiedz\u0119 do projektowania cz\u0105steczek wobec trudnych cel\u00f3w, takich jak BRD9, SMARCA2, KRAS i LRRK2. Wyk\u0142ad obejmie te\u017c [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"seminar-category":[],"coauthors":[],"class_list":["post-13488","seminar","type-seminar","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Protein degraders: New insights and twists of molecular mechanism and drug design - ICTER<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protein degraders: New insights and twists of molecular mechanism and drug design - ICTER\" \/>\n<meta property=\"og:description\" content=\"Prof. Ciulli opowie o degraderach bia\u0142ek, w tym PROTAC-ach i klejach molekularnych, kt\u00f3re kieruj\u0105 wybrane bia\u0142ka do ligaz E3, uruchamiaj\u0105c ich ubikwitynacj\u0119 i degradacj\u0119 w proteasomie. 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