{"id":7220,"date":"2023-05-10T08:59:57","date_gmt":"2023-05-10T08:59:57","guid":{"rendered":"https:\/\/icter.pl\/?post_type=grants&#038;p=7220"},"modified":"2026-07-23T10:02:01","modified_gmt":"2026-07-23T10:02:01","slug":"miniatura-6-nsc","status":"publish","type":"grants","link":"https:\/\/icter.jcd.pl\/pl\/grants\/miniatura-6-nsc\/","title":{"rendered":"MINIATURA 6 \/ NCN"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Tytu\u0142 projektu:<\/strong> Badania przesiewowe inhibitor\u00f3w HDAC z r\u00f3wnoczesnym odczytem zmian na poziomie transkryptomu i epigenomu w pojedynczych kom\u00f3rkach nowotworowych.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">W ramach grantu Miniatura prowadzone jest pilota\u017cowe badanie maj\u0105ce na celu przetestowanie profilowania odpowiedzi kom\u00f3rek nowotworowych na wybrane zwi\u0105zki chemiczne w rozdzielczo\u015bci pojedynczej kom\u00f3rki i pojedynczego klonu, z pe\u0142nym okre\u015bleniem zmian w transkryptomie i dost\u0119pno\u015bci chromatyny po podaniu leku. Badanie zosta\u0142o podzielone na kolejne etapy. Na pocz\u0105tku ustalony zostanie protok\u00f3\u0142 znakowania populacji j\u0105der kom\u00f3rkowych z \u0142\u0105cznym profilowaniem zmian transkryptomu i dost\u0119pno\u015bci chromatyny. Nast\u0119pnie, przy u\u017cyciu platformy high-throughput screening (HTS), zbadany zostanie wp\u0142yw wybranych inhibitor\u00f3w deacetylaz histonowych (HDACi) w r\u00f3\u017cnych st\u0119\u017ceniach na odpowied\u017a czterech ludzkich linii nowotworowych reprezentuj\u0105cych jedne z najcz\u0119stszych typ\u00f3w raka (pier\u015b, p\u0142uco, jelito grube, prostata). Ka\u017cdy indywidualny warunek eksperymentalny zostanie zakodowany, a nast\u0119pnie pogrupowany w celu przeprowadzenia bada\u0144 multiomicznych w obr\u0119bie pojedynczych kom\u00f3rek. Oddzielne biblioteki b\u0119d\u0105 sekwencjonowane w celu wygenerowania zestawu danych zawieraj\u0105cych wsp\u00f3lne profile transkryptomu i dost\u0119pno\u015bci chromatyny odpowiednio dla ka\u017cdego z warunk\u00f3w eksperymentalnych. Pozwoli to na przysz\u0142e op\u0142acalne HTS z fenotypowaniem pojedynczych kom\u00f3rek.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ca\u0142kowite dofinansowanie projektu wynosi 49 400 z\u0142.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tytu\u0142 projektu: Badania przesiewowe inhibitor\u00f3w HDAC z r\u00f3wnoczesnym odczytem zmian na poziomie transkryptomu i epigenomu w pojedynczych kom\u00f3rkach nowotworowych. W ramach grantu Miniatura prowadzone jest pilota\u017cowe badanie maj\u0105ce na celu przetestowanie profilowania odpowiedzi kom\u00f3rek nowotworowych na wybrane zwi\u0105zki chemiczne w rozdzielczo\u015bci pojedynczej kom\u00f3rki i pojedynczego klonu, z pe\u0142nym okre\u015bleniem zmian w transkryptomie i dost\u0119pno\u015bci chromatyny [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"coauthors":[50],"class_list":["post-7220","grants","type-grants","status-publish","hentry"],"acf":{"grant_name":"MINIATURA 6","grant_funding_amount":"","grant_funding_institution":"Narodowe Centrum Nauki","grant_cta_link":"","grant_status":"Zako\u0144czony","grant_funding_statement":"","grant_agreement_number":"2022\/06\/X\/NZ2\/01765","grant_lead_sp":"","grant_coordinator":"","grant_leader_person":[4168],"grant_funding_institution_sp":"","grant_funding_amount_pln":49400,"grant_funding_amount_eur":"","grant_start_date":"20221123","grant_end_date":"20231122"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MINIATURA 6 \/ NCN - ICTER<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MINIATURA 6 \/ NCN - ICTER\" \/>\n<meta property=\"og:description\" content=\"Tytu\u0142 projektu: Badania przesiewowe inhibitor\u00f3w HDAC z r\u00f3wnoczesnym odczytem zmian na poziomie transkryptomu i epigenomu w pojedynczych kom\u00f3rkach nowotworowych. W ramach grantu Miniatura prowadzone jest pilota\u017cowe badanie maj\u0105ce na celu przetestowanie profilowania odpowiedzi kom\u00f3rek nowotworowych na wybrane zwi\u0105zki chemiczne w rozdzielczo\u015bci pojedynczej kom\u00f3rki i pojedynczego klonu, z pe\u0142nym okre\u015bleniem zmian w transkryptomie i dost\u0119pno\u015bci chromatyny [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/icter.jcd.pl\/pl\/grants\/miniatura-6-nsc\/\" \/>\n<meta property=\"og:site_name\" content=\"ICTER\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/icterresearch\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-23T10:02:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/icter.jcd.pl\/wp-content\/uploads\/2021\/07\/bg6.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@icter_pl\" \/>\n<meta name=\"twitter:label1\" content=\"Szacowany czas czytania\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuta\" \/>\n\t<meta name=\"twitter:label2\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data2\" content=\"kwybranska@ichf.edu.pl\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/grants\\\/miniatura-6-nsc\\\/\",\"url\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/grants\\\/miniatura-6-nsc\\\/\",\"name\":\"MINIATURA 6 \\\/ NCN - ICTER\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/#website\"},\"datePublished\":\"2023-05-10T08:59:57+00:00\",\"dateModified\":\"2026-07-23T10:02:01+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/grants\\\/miniatura-6-nsc\\\/#breadcrumb\"},\"inLanguage\":\"pl-PL\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/grants\\\/miniatura-6-nsc\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/grants\\\/miniatura-6-nsc\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"MINIATURA 6 \\\/ NCN\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/#website\",\"url\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/\",\"name\":\"International Centre for Translational Eye Research\",\"description\":\"The International Center for Translational Eye Research\",\"publisher\":{\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/#organization\"},\"alternateName\":\"ICTER\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pl-PL\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/#organization\",\"name\":\"International Centre for Translational Eye Research\",\"alternateName\":\"ICTER\",\"url\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pl-PL\",\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/icter.jcd.pl\\\/wp-content\\\/uploads\\\/2021\\\/10\\\/logo-blue.png\",\"contentUrl\":\"https:\\\/\\\/icter.jcd.pl\\\/wp-content\\\/uploads\\\/2021\\\/10\\\/logo-blue.png\",\"width\":806,\"height\":122,\"caption\":\"International Centre for Translational Eye Research\"},\"image\":{\"@id\":\"https:\\\/\\\/icter.jcd.pl\\\/pl\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/icterresearch\",\"https:\\\/\\\/x.com\\\/icter_pl\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/international-centre-for-translational-eye-research\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"MINIATURA 6 \/ NCN - ICTER","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"pl_PL","og_type":"article","og_title":"MINIATURA 6 \/ NCN - ICTER","og_description":"Tytu\u0142 projektu: Badania przesiewowe inhibitor\u00f3w HDAC z r\u00f3wnoczesnym odczytem zmian na poziomie transkryptomu i epigenomu w pojedynczych kom\u00f3rkach nowotworowych. 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